© Dan McCloskey 2015 Contact
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Our laboratory studies cooperative behavior in the highly social naked mole-rat.
We use automated approaches in a laboratory housing enviornment to monitor movement, social interaction and object manipulation.
We utilize the CUNY High Performance Computing Center for data analytics on these measures.
These approaches allow us to identify individual differences in social behavior which can be used to measure neural correlates.
We use electrophysiological tools to monitor neuron function from the level of the isolated single cell to the whole brain.
Our methods range from patch clamp measures on cultured neurons through single channel and multi-channel recording of acutely isolated brain regions, to EEG in awake moving animals.
These approaches allow us to identify cell and curcuit level differences related to the seizure-proneness of naked mole-rats, and will eventually allow us to measure neural function related to social behavior.
Using unbiased sampling and 3D reconstruction of confocal image stacks we measure structures of interest in the study of the social behavior and epilepsy.
Additional use of new high throughput quantitatie anatomy techniques allows for rapid estimates of total neuron number in specific brain regions.
Computational data mining approaches allow for analyses and cross-species comparison based on publicly available datasets.
There's plenty more at http://brainy.ac , the worlds first crowdfunding website devoted to support students engaged in neuroscience research. Check out our virtual interactive 3D brain and see some more amazing neuroscience projects. For a donation of $20, you can name one of the neurons in our 3D brain and support the next generation of neuroscience superstars!